May 5, 2016Open Access

Ventricular Tachycardia Ablation versus Escalation of Antiarrhythmic Drugs

Structured PICO

Does catheter ablation reduce the composite of death, ventricular tachycardia storm, or appropriate ICD shock in patients with ischemic cardiomyopathy and an ICD who have ventricular tachycardia despite antiarrhythmic drug therapy?

Population

Patients with ischemic cardiomyopathy and an ICD who had ventricular tachycardia despite antiarrhythmic drug therapy

Intervention

Catheter ablation

Comparator

Escalation in antiarrhythmic drug therapy

Outcome

Composite primary outcome of death, ventricular tachycardia storm, or appropriate ICD shockcomposite

In patients with ischemic cardiomyopathy and refractory ventricular tachycardia, catheter ablation is superior to escalating antiarrhythmic drugs in reducing the composite of death, VT storm, or appropriate ICD shocks.

Abstract

In patients with ischemic cardiomyopathy and an ICD who had ventricular tachycardia despite antiarrhythmic drug therapy, there was a significantly lower rate of the composite primary outcome of death, ventricular tachycardia storm, or appropriate ICD shock among patients undergoing catheter ablation than among those receiving an escalation in antiarrhythmic drug therapy. (Funded by the Canadian Institutes of Health Research and others; VANISH ClinicalTrials.gov number, NCT00905853.).

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Discussion

Journals

New England Journal of Medicine

Institutions

Brigham and Women's Hospital

McGill University

Western University

References and Citations

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