Adding intensive systolic blood pressure goals (<120 mm Hg) for high-risk patients prevents an estimated 43,000 and 35,000 annual CVD events incremental to JNC8 and JNC7 guidelines, respectively.
Does adding intensive blood pressure goals to current guidelines improve cost-effectiveness and reduce CVD events in hypertensive adults aged 35-74 years?
Adding intensive blood pressure goals for high-risk groups to current national hypertension treatment guidelines prevents additional CVD deaths while saving costs or remaining cost-effective.
The population health effect and cost-effectiveness of implementing intensive blood pressure goals in high-cardiovascular disease (CVD) risk adults have not been described. Using the CVD Policy Model, CVD events, treatment costs, quality-adjusted life years, and drug and monitoring costs were simulated over 2016 to 2026 for hypertensive patients aged 35 to 74 years. We projected the effectiveness and costs of hypertension treatment according to the 2003 Joint National Committee (JNC) -7 or 2014 JNC8 guidelines, and then for adults aged ≥50 years, we assessed the cost-effectiveness of adding an intensive goal of systolic blood pressure <120 mm Hg for patients with CVD, chronic kidney disease, or 10-year CVD risk ≥15%. Incremental cost-effectiveness ratios <50 000 per quality-adjusted life years gained were considered cost-effective. JNC7 strategies treat more patients and are more costly to implement compared with JNC8 strategies. Adding intensive systolic blood pressure goals for high-risk patients prevents an estimated 43 000 and 35 000 annual CVD events incremental to JNC8 and JNC7, respectively. Intensive strategies save costs in men and are cost-effective in women compared with JNC8 alone. At a willingness-to-pay threshold of 50 000 per quality-adjusted life years gained, JNC8+intensive had the highest probability of cost-effectiveness in women (82%) and JNC7+intensive the highest probability of cost-effectiveness in men (100%). Assuming higher drug and monitoring costs, adding intensive goals for high-risk patients remained consistently cost-effective in men, but not always in women. Among patients aged 35 to 74 years, adding intensive blood pressure goals for high-risk groups to current national hypertension treatment guidelines prevents additional CVD deaths while saving costs provided that medication costs are controlled.
Moise et al. (Mon,) conducted a other in Hypertension. Intensive blood pressure goals vs. JNC7 or JNC8 guidelines alone was evaluated on Cost-effectiveness (incremental cost-effectiveness ratios <$50 000 per QALY gained) and CVD events. Adding intensive systolic blood pressure goals (<120 mm Hg) for high-risk patients prevents an estimated 43,000 and 35,000 annual CVD events incremental to JNC8 and JNC7 guidelines, respectively.