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Operant conditioning of heart rate (HR) was carried out in 8 patients with premature ventricular contractions (PVCs). All of the patients showed some degree of HR control. Five of these patients showed a decrease in PVCs in association with the learning of HR control. Four patients have shown persistence of a low PVC frequency after study, the longest followup being 21 months. Pharmacologic studies suggested that decreased PVC frequency was mediated by diminished sympathetic tone in 1 patient and increased vagal tone in another. These findings suggest that some aspects of cardiac ventricular function can be brought under voluntary control. Once such control has been acquired, it can mediate clinically significant changes in cardiac function.
Weiss et al. (Thu,) studied this question.