What question did this study set out to answer?

To define optimal preoperative P2Y12 reaction unit (PRU) target thresholds to mitigate perioperative bleeding and clotting risks.

August 26, 2015Neurosurgery79 citations

P2Y12 Reaction Units

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BDBadih Daou RSRobert M. Starke NCNohra Chalouhi

Key Points

To define optimal preoperative P2Y12 reaction unit (PRU) target thresholds to mitigate perioperative bleeding and clotting risks.
Assessed preoperative platelet reactivity ranges measured by P2Y12 reaction units (PRU) against surgical complication profiles.
Identified acceptable preoperative PRU targets between 60 and 240, with an optimal therapeutic range between 70 and 150.
Associated PRU values below 60 with increased odds of hemorrhagic complications and values above 240 with increased odds of thromboembolic events.

Abstract

Target preoperative PRU values should be between 60 and 240 and ideally between 70 and 150. Values below this range and above it carry higher odds of hemorrhagic and thromboembolic complications, respectively.

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P2Y12 Reaction Units

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