Endothelial dysfunction is prevalent in essential hypertension, shares a cyclical pathophysiological relationship with the condition, and can be improved by various antihypertensive therapies.
This review summarizes the mechanisms, prognostic significance, and potential pharmacological reversal of endothelial dysfunction in essential hypertension.
Although the endothelium has a number of important functions, the term endothelial dysfunction is commonly used to describe impairment in its vasodilatory capacity. It is increasingly recognized that this is related to hypertension, although whether it predates essential hypertension or is a consequence of it is still unknown. In this review, we explore the mechanisms of endothelial dysfunction in essential hypertension, its prognostic significance and methods of pharmacological reversal.
Mordi et al. (Fri,) conducted a review in Essential hypertension and endothelial dysfunction. Antihypertensive therapies (ACE inhibitors, ARBs, aldosterone antagonists, CCBs) was evaluated. Endothelial dysfunction is prevalent in essential hypertension, shares a cyclical pathophysiological relationship with the condition, and can be improved by various antihypertensive therapies.