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Objective The aim of our study was to analyse the frequency of β1 and/or β2 adrenergic receptor polymorphisms in patients with takotsubo cardiomyopathy (TTC).Methods and resultsβ1 and/or β2 adrenergic receptor polymorphisms in 61 patients with TTC were compared with 109 controls. The β1 adrenoreceptor (amino acid position 389) genotype frequencies were signifi cantly diff erent in the two groups; assuming a recessive model for the allelic variant coding for Arg on this position, the odds ratio was 3.14, 95% CI 1.55-6.37 (P= 0.0015). The β2 adrenoreceptor amino acid position 27 genotype was signifi cantly diff erent and assuming a recessive model for the allelic variant coding for Gln on this position, the odds ratio was 0.29, 95% CI 0.12-0.74 (P= 0.009).Conclusions This study showed for the fi rst time an association between TTC phenotype and β1 adrenoreceptor gene polymorphisms. Beta adrenoreceptors gene polymorphisms are probably disease modifi ers, and any risk estimate should be based on a combination of genotypes and on interactions with other genes and environmental features.
Vriz et al. (Thu,) studied this question.