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We examined the influence of serotonin (5-HT), an important state-dependent neuromodulator, on synaptic transmission to hypoglossal motoneurons (HMs). Our data demonstrate that 5-HT acts presynaptically to inhibit excitatory (glutamatergic) synaptic currents recorded in HMs. We discuss this result in relation to the role of 5-HT in state-dependent modulation of respiration-related activity in HMs.
Singer et al. (1996) studied this question.