ICD implantation in high-risk hypertrophic cardiomyopathy patients yielded an appropriate discharge rate of 4-5% per patient-year, though no single risk marker predicted future arrhythmic events.
Cohort (n=50)
What is the incidence of adequate ICD interventions in patients with hypertrophic cardiomyopathy at high risk for sudden cardiac death?
In high-risk HCM patients, the incidence of appropriate ICD discharges is 4-5% per year, supporting current risk stratification despite no single risk marker being predictive alone.
INTRODUCTION: Although the incidence of sudden cardiac death (SCD) is as low as 1%/year in un-selected patients (pts) with hypertrophic cardiomyopathy (HCM), higher-risk populations may benefit from prophylactic implantation of an ICD. Risk assessment in HCM is thus important and currently based on the presence or absence of different risk markers (RM). STUDY AIM: The objective of this study is to correlate the incidence of adequate ICD interventions in HCM with the presence of different RM. METHODS: Fifty pts with HCM had ICD implantation, either for secondary (n = 2/4%), or primary prophylaxis of SCD (n = 48/96%). ICD for primary prophylaxis pts had more than 1 (2-4) RM. Outflow obstruction was present in 25 pts, the other 25, including I patient each after septal ablation and myectomy, were non-obstructive. ICD memories were read out and interpreted in accordance with established guidelines. RESULTS: The number of RM per patient was 1.7 +/- 0.8. During follow-up of 2.0 +/- 0.5 0.2-6.3 years, adequate ICD interventions (11 episodes) were documented in 5, inadequate ICD interventions in 3 pts.Thirteen pts had at least I episode of atrial fibrillation. Pts with versus without events had a longer follow-up (3.2 +/- 4.3 vs. 1.8 +/- 2.6 years, P < 0.05), and were more frequently nonobstructive (all 5; P = 0.05).Within the time period observed no single RM was predictive for arrhythmic events. CONCLUSIONS: Incidence of appropriate ICD discharges was 4-5%/patient-year, supporting the proposed risk stratification. No single RM was predictive for future arrhythmic events.
Prinz et al. (Fri,) conducted a cohort in Hypertrophic cardiomyopathy (n=50). ICD implantation was evaluated on Adequate ICD interventions. ICD implantation in high-risk hypertrophic cardiomyopathy patients yielded an appropriate discharge rate of 4-5% per patient-year, though no single risk marker predicted future arrhythmic events.