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The transcription factor EB (TFEB) plays a pivotal role in the regulation of basic cellular processes, such as lysosomal biogenesis and autophagy. The subcellular localization and activity of TFEB are regulated by mechanistic target of rapamycin (mTOR)-mediated phosphorylation, which occurs at the lysosomal surface. Phosphorylated TFEB is retained in the cytoplasm, whereas dephosphorylated TFEB translocates to the nucleus to induce the transcription of target genes. Thus, a lysosome-to-nucleus signaling pathway regulates cellular energy metabolism through TFEB. Recently, in vivo studies have revealed that TFEB is also involved in physiological processes, such as lipid catabolism. TFEB has attracted a lot of attention owing to its ability to induce the intracellular clearance of pathogenic factors in a variety of murine models of disease, such as Parkinson's and Alzheimer's, suggesting that novel therapeutic strategies could be based on the modulation of TFEB activity. In this Cell Science at a Glance article and accompanying poster, we present an overview of the latest research on TFEB function and its implication in human diseases.
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Gennaro Napolitano
Istituto Universitario di Studi Superiori di Pavia
Andrea Ballabio
University of Siena
Journal of Cell Science
Baylor College of Medicine
Federico II University Hospital
Institute of Genetics and Biophysics
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Napolitano et al. (Thu,) studied this question.
synapsesocial.com/papers/69d7c8b433ca018b39ae2cd2 — DOI: https://doi.org/10.1242/jcs.146365