Higher body mass index in young men was associated with a steeply rising risk of early heart failure, increasing nearly 10-fold (HR 9.21; 95% CI 6.57-12.92) for those with a BMI ≥35 kg/m2.
Cohort (n=1,610,437)
Does higher body mass index in adolescence increase the risk of early hospitalization with heart failure in adulthood among men?
Higher BMI in adolescence, even within the high-normal range, is associated with a steeply rising, up to 10-fold increased risk of early heart failure in adulthood.
Estimación del efecto: HR 9.21 (95% CI 6.57-12.92)
AIMS: To study the relation between body mass index (BMI) in young men and risk of early hospitalization with heart failure. METHODS AND RESULTS: In a prospective cohort study, men from the Swedish Conscript Registry investigated 1968-2005 (n = 1 610 437; mean age, 18.6 years were followed 5-42 years (median, 23.0 years; interquartile range, 15.0-32.0), 5492 first hospitalizations for heart failure occurred (mean age at diagnosis, 46.6 (SD 8.0) years). Compared with men with a body mass index (BMI) of 18.5-20.0 kg/m2, men with a BMI 20.0-22.5 kg/m2 had an hazard ratio (HR) of 1.22 (95% CI, 1.10-1.35), after adjustment for age, year of conscription, comorbidities at baseline, parental education, blood pressure, IQ, muscle strength, and fitness. The risk rose incrementally with increasing BMI such that men with a BMI of 30-35 kg/m2 had an adjusted HR of 6.47 (95% CI, 5.39-7.77) and those with a BMI of ≥35 kg/m2 had an HR of 9.21 (95% CI, 6.57-12.92). The multiple-adjusted risk of heart failure per 1 unit increase in BMI ranged from 1.06 (95% CI, 1.02-1.11) in heart failure associated with valvular disease to 1.20 (95% CI, 1.18-1.22) for cases associated with coronary heart disease, diabetes, or hypertension. CONCLUSION: We found a steeply rising risk of early heart failure detectable already at a normal body weight, increasing nearly 10-fold in the highest weight category. Given the current obesity epidemic, heart failure in the young may increase substantially in the future and physicians need to be aware of this.
Rosengren et al. (Thu,) conducted a cohort in early heart failure (n=1,610,437). Body mass index (BMI) vs. BMI 18.5-20.0 kg/m2 was evaluated on early hospitalization with heart failure (HR 9.21, 95% CI 6.57-12.92). Higher body mass index in young men was associated with a steeply rising risk of early heart failure, increasing nearly 10-fold (HR 9.21; 95% CI 6.57-12.92) for those with a BMI ≥35 kg/m2.