Multi-modality stacked deep polynomial network based feature learning for Alzheimer's disease diagnosis

Feature representation is the critical factor for the computer-aided Alzheimer's disease (AD) diagnosis. Deep polynomial network (DPN) is a novel deep learning algorithm, which can effectively learn feature representation from small samples. In this work, a stacked DPN (S-DPN) algorithm is proposed to further improve feature representation. We then propose a multi-modality S-DPN (MM-S-DPN) algorithm to fuse multi-modality neuroimaging data and learn more discriminative and robust feature representation for AD classification. Experiments are performed on ADNI dataset with MRI and PET images as multi-modality data. The results indicate that S-DPN is superior to DPN and stacked auto-encoder algorithms. Moreover, MM-S-DPN achieves best performance compared with single-modality S-DPN and other multi-modality feature learning based algorithms.