Does gemfibrozil 1200 mg daily improve lipid profiles in patients with hypertriglyceridaemia or hypercholesterolaemia?
Gemfibrozil 1200 mg daily effectively reduces triglycerides and increases HDL cholesterol in patients with dyslipidemia.
During treatment with gemfibrozil, 1200 mg daily, total serum triglyceride levels were reduced in 7 of the 11 patients, owing chiefly to a fall in VLDL triglyceride levels. Total serum cholesterol responded variably, falling in a majority of patients with hypercholesterolaemia. High density lipoprotein cholesterol rose during treatment in patients who had either hypertriglyceridaemia or hypercholesterolaemia.
Janus et al. (Sun,) studied this question.