May 19, 2016
Gender Differences in Autonomic Control of the Cardiovascular System
Key Result
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Structured PICO
Are there gender differences in autonomic control of the cardiovascular system?
P
Population
Men and women in states of rest, stress, and cardiac disease
O
Outcome
Gender differences in autonomic nervous system (ANS) activitysurrogate
There is increasing evidence of significant gender differences in autonomic nervous system activity, which may have implications for targeted therapy in cardiovascular diseases.
Abstract
BACKGROUND: The autonomic nervous system (ANS) is a key regulator of the cardiovascular system. The two arms of the ANS, sympathetic and parasympathetic (vagal) have co-regulatory effects on cardiac homeostasis. ANS modulation and dysfunction are also believed to affect various cardiac disease states. Over the past decade, there has been increasing evidence suggesting gender differences in ANS activity. METHODS: In multiple previous studies, ANS activity was primarily assessed using heart rate variability, muscle sympathetic nerve activity, coronary blood flow velocity, and plasma biomarkers. Heart rate variability is a non-invasive measure, which can be analyzed in terms of low frequency and high frequency oscillations, which indicate the sympathetic and parasympathetic tone, respectively. These measures have been studied between women and men in states of rest and stress, and in cardiac disease. CONCLUSION: Studies support the concept of a significant gender difference in ANS activity. Further studies are indicated to elucidate specific differences and mechanisms, which could guide targeted therapy of various cardiovascular disease states.