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Antibodies against heat-aggregated human IgG (AHG) were raised in rabbits and those against immune complex (IC) of tetanus toxoid and its human antitoxin (T/aT) in rabbits and mice. These antisera were analyzed by the Ouchterlony double diffusion technique against native monomeric human IgG (NHG), AHG and chemically linked human IgG (poly-G). The appearance of neoantigens was demonstrated with human IgG bound to its corresponding antigen or denaturated nonspecifically. The results are indicative of the existence of a common determinant shared with AHG and T/aT, in addition to those of their own.
Eiseman et al. (Wed,) studied this question.