Transplacental pharmacotherapy with intravenous magnesium and lidocaine successfully restored sinus rhythm in 1 fetus at 27 weeks gestation with congenital long QT syndrome.
Case Report (n=1)
A 27-week fetus evaluated for bradycardia and hydrops was found to have anti-SSA-negative 2° atrioventricular block and ventricular tachycardia. A presumptive diagnosis of fetal long QT syndrome was made. Transplacental pharmacotherapy with intravenous magnesium and lidocaine restored sinus rhythm. At 30 6/7 weeks, the infant was delivered due to premature labor. Despite postnatal treatment with mexiletine and propranolol, she developed torsades de pointes. Ultimately, a de novo KCNH2 G628S mutation was diagnosed. She received an implantable cardiac defibrillator at 5 months of age. Early diagnosis and a multidisciplinary approach allowed successful in utero treatment and anticipatory postnatal management. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 45:168-170, 2017.
Crimmins et al. (Fri,) conducted a case report in Congenital long QT syndrome (n=1). Transplacental pharmacotherapy (intravenous magnesium and lidocaine) was evaluated on Restoration of sinus rhythm. Transplacental pharmacotherapy with intravenous magnesium and lidocaine successfully restored sinus rhythm in 1 fetus at 27 weeks gestation with congenital long QT syndrome.