Does the ALDH2-deficient genotype increase the risk of poor coronary collateral circulation in patients with chronic ischemia?
ALDH2 deficiency is associated with poor coronary collateral circulation in chronic ischemia, suggesting genotype-guided therapeutic individualization may be beneficial, particularly in East Asian populations.
This study demonstrated that ALDH2 possesses an intrinsic capacity to regulate angiogenesis via hypoxia-inducible factor-1α and vascular endothelial growth factor. Patients with ALDH2-deficient genotype displayed a higher risk of developing poor CCC. Therapeutic individualization based on ALDH2 allele distribution may thus improve the therapeutic benefit, especially in the East Asian decedents.
Liu et al. (Fri,) studied this question.