Symptomatic presentation at diagnosis and spontaneous type I ECG were significantly associated with future arrhythmic events, occurring at a rate of 4.5% per year in symptomatic patients vs 0% in asymptomatic patients.
Cohort (n=128)
What are the risk factors predicting future arrhythmic events in young patients with Brugada syndrome?
In young patients with Brugada syndrome, symptomatic presentation, spontaneous type I ECG, atrial arrhythmias, and conduction abnormalities are significant predictors of future lethal arrhythmic events.
Absolute Event Rate: 4.5% vs 0%
AIMS: To investigate the clinical characteristics, prognoses, and presence of risk factors in young patients with Brugada syndrome (BS). METHODS AND RESULTS: A consecutive cohort of 128 young BS patients (≤25 years old at diagnosis) was analysed. Eighty-eight patients (69%) were asymptomatic, whereas 40 (31%) presented with clinical manifestations of BS. Markers of prognosis and risk were identified upon comparison of these two groups. A history of malignant syncope was strong predictors of ventricular arrhythmic events. Family history of sudden cardiac death (SCD) and mutations in the SCN5A gene did not associate with increased risk. Symptomatic patients presented with significantly abnormal baseline electrical characteristics when compared with the asymptomatic cohort, including spontaneous type I electrocardiograph (ECG) patterns, sinus node dysfunction (SND), first-degree atrioventricular (AV) block, and intra-ventricular conduction delay. The symptomatic group more frequently exhibited atrial arrhythmias. Electrophysiological studies resulted positive more frequently in symptomatic patients, but no risk association for future events could be determined. During the follow-up period (mean: 65 months), 10 arrhythmic events occurred in nine symptomatic patients (event rate: 4.5% per year). No events occurred in the asymptomatic group. Variables significantly associated with arrhythmic events during follow-up were presence of symptoms at diagnosis and spontaneous type I ECG. The presence of atrial arrhythmias and conduction abnormalities was also associated with the risk of arrhythmic events during follow-up. CONCLUSION: Symptomatic BS in the young age is a rare but malignant condition that can manifest with a spectrum of electrical abnormalities (i.e. SND, atrial tachycardias, AV block, and infra-nodal conduction delay) and result in the extreme cases in lethal arrhythmic events and SCD.
Corcia et al. (Thu,) conducted a cohort in Brugada syndrome (n=128). Symptomatic presentation vs. Asymptomatic presentation was evaluated on Arrhythmic events during follow-up. Symptomatic presentation at diagnosis and spontaneous type I ECG were significantly associated with future arrhythmic events, occurring at a rate of 4.5% per year in symptomatic patients vs 0% in asymptomatic patients.