The cerebral blood flow to cardiac output ratio index decreased by 1.3% per decade across the adult lifespan (P<0.001) and was inversely associated with body mass index (β = -0.33, P<0.001).
Observational
Effect estimate: β = -0.33
p-value: p=<0.001
max), and total brain volume were measured to assess their effects on the cardiac output-cerebral blood flow relationship. Cerebral blood flow/cardiac output ratio index decreased by 1.3% per decade associated with decreases in cerebral blood flow ( P < 0.001), while cardiac output remained unchanged. Women had higher cerebral blood flow, lower cardiac output, and thus higher cerebral blood flow/cardiac output ratio index than men across the adult lifespan. Age, body mass index, carotid-femoral pulse wave velocity, and arterial pressure all had negative correlations with cerebral blood flow and cerebral blood flow/cardiac output ratio index ( P < 0.05). Multivariable analysis adjusted for sex, age showed that only body mass index was negatively associated with cerebral blood flow/cardiac output ratio index (β = -0.33, P < 0.001). These findings demonstrated that cardiac output distributed to the brain has sex differences and decreases across the adult lifespan and is inversely associated with body mass index.
Xing et al. (Fri,) reported a observational. The cerebral blood flow to cardiac output ratio index decreased by 1.3% per decade across the adult lifespan (P<0.001) and was inversely associated with body mass index (β = -0.33, P<0.001).