Enantioselective Synthesis of Trisubstituted Allenes via Cu(I)-Catalyzed Coupling of Diazoalkanes with Terminal Alkynes

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Abstract

A highly enantioselective synthesis of trisubstituted allenes has been achieved through Cu(I)-catalyzed cross-coupling of aryldiazoalkanes and terminal alkynes with chiral bisoxazoline ligands. Alkynyl migratory insertion of Cu(I) carbene is proposed as the key step for the construction of axial chirality.

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Discussion

Journals

Journal of the American Chemical Society

Institutions

Chinese Academy of Sciences

Peking University

Beijing National Laboratory for Molecular Sciences

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