Does renal denervation attenuate multi-organ fibrosis and improve vascular remodeling in rats with transverse aortic constriction induced cardiomyopathy?
In a rat model of TAC-induced cardiomyopathy, renal denervation attenuated multi-organ fibrosis and improved vascular remodeling, potentially via RAAS and oxidative stress inhibition.
RDN can attenuate multi-organ fibrosis and improve vascular remodeling independent of BP and HR change in TAC-induced cardiomyopathy. These effects of RDN may be associated with the direct inhibition of renin-angiotensin-aldosterone system and oxidative stress.
Wang et al. (Fri,) studied this question.