Single passive leg movement (sPLM) evoked a similar peak leg blood flow response compared to standard PLM (878 vs 993 ml/min) without inducing potentially confounding chronotropic responses.
Does single passive leg movement (sPLM) induce similar peripheral hyperemia as standard PLM without a central chronotropic response in healthy subjects?
Single passive leg movement (sPLM) is a simplified method to assess vascular function that induces significant hyperemia without confounding central hemodynamic responses.
Absolute Event Rate: 878% vs 993%
Passive leg movement (PLM)-induced hyperemia is a novel approach to assess vascular function, with a potential clinical role. However, in some instances, the varying chronotropic response induced by PLM has been proposed to be a potentially confounding factor. Therefore, we simplified and modified the PLM model to require just a single PLM (sPLM), an approach that may evoke a peripheral hemodynamic response, allowing a vascular function assessment, but at the same time minimizing central responses. To both characterize and assess the utility of sPLM, in 12 healthy subjects, we measured heart rate (HR), stroke volume, cardiac output (CO), mean arterial pressure (MAP), leg blood flow (LBF), and calculated leg vascular conductance (LVC) during both standard PLM, consisting of passive knee flexion and extension performed at 1 Hz for 60 s, and sPLM, consisting of only a single passive knee flexion and extension over 1 s. During PLM, MAP transiently decreased (5 ± 1 mmHg), whereas both HR and CO increased from baseline (6.0 ± 1.1 beats/min, and 0.8 ± 0.01 l/min, respectively). Following sPLM, MAP fell similarly (5 ± 2 mmHg; P = 0.8), but neither HR nor CO responses were identifiable. The peak LBF and LVC response was similar for PLM (993 ± 189 ml/min; 11.9 ± 1.5 ml·min −1 ·mmHg −1 , respectively) and sPLM (878 ± 119 ml/min; 10.9 ± 1.6 ml·min −1 ·mmHg −1 , respectively). Thus sPLM represents a variant of the PLM approach to assess vascular function that is more easily performed and evokes a peripheral stimulus that induces a significant hyperemia, but does not generate a potentially confounding, chronotropic response, which may make sPLM more useful clinically. NEW & NOTEWORTHY Using the single passive leg movement (PLM) technique, a variant of the vascular function assessment PLM, we have identified a novel peripheral vascular assessment method that is more easily performed than PLM, which, by not evoking potentially confounding central hemodynamic responses, may be more useful clinically.
Venturelli et al. (Mon,) conducted a other in Healthy (n=12). Single passive leg movement (sPLM) vs. Standard passive leg movement (PLM) was evaluated on Peak leg blood flow (LBF). Single passive leg movement (sPLM) evoked a similar peak leg blood flow response compared to standard PLM (878 vs 993 ml/min) without inducing potentially confounding chronotropic responses.