Higher active serum calcium levels were associated with a reduced risk of incident hypertension in middle-aged men (adjusted HR per 1 SD increase 0.82; 95% CI 0.71-0.94).
Cohort (n=1,562)
Does higher active serum calcium concentration reduce the risk of incident hypertension in middle-aged normotensive men?
Higher active serum calcium levels are independently associated with a reduced risk of developing hypertension in middle-aged men over a 25-year follow-up.
Hazard Ratio: 0.82 (95% CI 0.71–0.94)
Purpose Calcium, which is one the most abundant mineral elements in the body, has been suggested to be involved in blood pressure regulation. We aimed to assess the association of active serum calcium (which is the ionised and physiologically active form of serum calcium) with the future risk of hypertension. Methods The active serum calcium concentration was assessed at baseline in the Finnish Kuopio Ischemic Heart Disease population-based prospective cohort study of 1562 normotensive men aged 42-61 years at baseline. Cox proportional hazard models were used to assess the hazard ratios (95% confidence intervals (CIs)) for incident hypertension. Results During a median follow-up of 24.9 years, 247 men developed new-onset hypertension. Active serum calcium was inversely associated with incident hypertension in an approximately linear fashion. In age-adjusted analysis, the hazard ratio for hypertension per 1 standard deviation increase in active serum calcium was 0.86 (95% CI 0.76-0.98), which remained consistent after adjustment for several established risk factors and potential confounders 0.82 (0.71-0.94). In a comparison of extreme quintiles of active serum calcium levels, the corresponding adjusted hazard ratios were 0.59 (95% CI 0.39-0.90) and 0.54 (95% CI 0.35-0.82), respectively. Conclusion Active serum calcium is protective of future hypertension in a middle-aged male Caucasian population. Further research is needed to confirm these findings and help unravel the mechanistic pathways of calcium in the pathogenesis of hypertension.
Kunutsor et al. (Fri,) conducted a cohort in Normotension (n=1,562). Active serum calcium vs. Lower active serum calcium levels was evaluated on Incident hypertension (HR 0.82, 95% CI 0.71-0.94). Higher active serum calcium levels were associated with a reduced risk of incident hypertension in middle-aged men (adjusted HR per 1 SD increase 0.82; 95% CI 0.71-0.94).
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