Presymptomatic C9ORF72 expansion carriers show early brain volume and connectivity deficits, suggesting aberrant network patterning or an early neurodegeneration prodrome.
expansion carriers exhibit functionally compensated brain volume and connectivity deficits that are similar, though less severe, to those reported during the symptomatic phase. The early adulthood emergence of these deficits suggests that they represent aberrant network patterning during development, an early neurodegeneration prodrome, or both.
Lee et al. (Sat,) studied this question.