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The article covers the histochemical features of parodontal-gingival complex tissues in parodontopathy in the experiment on animals. It was found that the introduction of pyrimidine derivatives leads to the activation of RNA synthesis in cells of epithelium and connective tissue of the gingiva and to the pronounced mobilization and activation of mast cells of connective tissue. The examined animals have the same changes in RNA, glycogen and acid mucopolysaccharides distribution as in humans with parodontopathy. This makes periodontal disease in cloven-hoofed a very promising model for studying parodontopathy in humans.
Sirak et al. (Fri,) studied this question.