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African swine fever is an acute hemorrhagic disease of pigs. Extensive recent spread in the Russian Federation and Eastern Europe has increased the risk to global pig production. The virus is a large DNA virus and is the only member of the Asfarviridae family. In pigs, the virus replicates predominantly in macrophages. We review how the virus overcomes the barriers to replication in the macrophage and the virus mechanism to inhibit key host defense pathways.
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Ana Luísa Reis
Christopher L. Netherton
Linda K. Dixon
Journal of Virology
The Pirbright Institute
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Reis et al. (Thu,) studied this question.
www.synapsesocial.com/papers/69d9ca0a6b6d1f62eea3c133 — DOI: https://doi.org/10.1128/jvi.02338-16
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