Atrial fibrillation rhythm was associated with a sharp decrease in left atrial appendage flow velocity compared to sinus rhythm (26.22 vs 61.87 mm/s; P<0.001), independent of CHA2DS2-VASc score.
Observational (n=98)
Do atrial fibrillation rhythm and CHA2DS2-VASc score correlate with decreased left atrial appendage flow velocity?
Atrial fibrillation rhythm causes a sharp decrease in left atrial appendage flow velocity independent of CHA2DS2-VASc score, whereas in sinus rhythm, higher CHA2DS2-VASc scores correlate with decreased flow velocity.
Absolute Event Rate: 26.22% vs 61.87%
p-value: p=<0.001
Background The CHA 2 DS 2 ‐VASc score is a classic predictor of stroke in patients with atrial fibrillation (AF). Decreased left atrial appendage flow velocity (LAA‐FV) reflects the blood stasis, and left atrial (LA) strain is a manifestation of atrial remodeling. This study aimed to explore the effects of AF rhythm and CHA 2 DS 2 ‐VASc score in the development of thrombogenesis and their potential correlation with LAA‐FV and LA strain. Hypothesis AF rhythm and high CHA 2 DS 2 ‐VASc score correlate independently with decreased LAA‐FV , which can be predicted by LA strain. Methods In 98 AF patients, LAA‐FV was measured by transesophageal echocardiography and LA strain was measured by transthoracic echocardiography. Results LA A‐FV decreased sharply in the AF rhythm group (26.22 vs 61.87 mm/s; P < 0.001), and CHA 2 DS 2 ‐VASc score did not differ between the decreased and normal LAA‐FV groups in all patients ( P = 0.289). However, in sinus rhythm (SR), LA A‐FV was associated with CHA 2 DS 2 ‐VASc score (coefficient = −0.317, P = 0.013), and the CHA 2 DS 2 ‐VASc score differed between the normal and decreased LAA‐FV groups (2 0–7 vs 3 0–6, respectively; P = 0.038). Moreover, LA strain was a predictor of LAA‐FV in both AF rhythm and SR, whereas a peak positive systolic strain divided by LA volume index <0.744 predicted decreased LAA‐FV . Conclusions AF rhythm caused a sharp decrease in LA A‐FV independent of CHA 2 DS 2 ‐VASc score. In SR, the CHA 2 DS 2 ‐VASc score correlated negatively with LAA‐FV . LA strain was a predictor of LAA‐FV in both SR and AF rhythm.
Zuo et al. (Wed,) conducted a observational in Atrial fibrillation (n=98). Atrial fibrillation rhythm vs. Sinus rhythm was evaluated on Left atrial appendage flow velocity (LAA-FV) (p=<0.001). Atrial fibrillation rhythm was associated with a sharp decrease in left atrial appendage flow velocity compared to sinus rhythm (26.22 vs 61.87 mm/s; P<0.001), independent of CHA2DS2-VASc score.