Noradrenaline at 100 nM significantly increased radial medial hydraulic permeability by 61% while decreasing total wall hydraulic conductance in rat abdominal aortas.
Does noradrenaline affect the hydraulic conductance of arterial intima and media?
Noradrenaline application increases total arterial wall resistance by increasing intimal resistance, despite decreasing medial resistance.
Effect estimate: 61% increase
Absolute Event Rate: 6.97% vs 4.33%
p-value: p=4.50 x 10^-8
, attributed to the opening of the ECM. Conversion of permeabilities to layer-specific resistances revealed that although the total wall resistance increased, medial resistance decreased, suggesting an increase in intimal resistance upon application of NA.
Chooi et al. (Mon,) conducted a other in Healthy (animal model) (n=8). Noradrenaline vs. Baseline (0 M NA) was evaluated on Radial medial hydraulic permeability (K1_1) (61% increase, p=4.50 x 10^-8). Noradrenaline at 100 nM significantly increased radial medial hydraulic permeability by 61% while decreasing total wall hydraulic conductance in rat abdominal aortas.
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