Every 10 mm Hg systolic blood pressure lowering with medical therapy reduces cardiovascular disease events by 20%, coronary heart disease by 17%, stroke by 27%, and heart failure by 28%.
Does medical therapy to lower systolic blood pressure by 10 mm Hg reduce cardiovascular events in individuals with hypertension?
Lowering systolic blood pressure by 10 mm Hg significantly reduces the risk of major cardiovascular events, reinforcing the importance of BP control in CVD prevention.
E levated blood pressure (BP) is a causal risk factor for cardiovascular disease (CVD). Epidemiological analyses have established the graded and continuous association between higher BP and CVD. Moreover, randomized clinical trials among individuals with hypertension have demonstrated, in aggregate, a reduction in CVD events by 20%, coronary heart disease (CHD) by 17%, stroke by 27%, and heart failure by 28% for every 10 mm Hg systolic BP (SBP) lowering with medical therapy. 1 Therefore, prevention, detection, treatment, and control of elevated BP, and its clinical correlate hypertension, is an important public health priority and a primary target for CVD prevention.
Karmali et al. (Tue,) conducted a review in Hypertension. Blood pressure lowering medical therapy was evaluated on Cardiovascular disease events. Every 10 mm Hg systolic blood pressure lowering with medical therapy reduces cardiovascular disease events by 20%, coronary heart disease by 17%, stroke by 27%, and heart failure by 28%.