Lewis Acid‐Mediated 3+3 Annulation for the Construction of Substituted Pyrimidine and Pyridine Derivatives

Abstract A direct and single‐step procedure towards substituted pyrimidine and pyridine derivatives via Lewis acid‐promoted 3+3 annulation between 3‐ethoxycyclobutanones and enamines or amidines is presented. Diverse substituted pyrimidine and pyridine derivatives were obtained in good to high yields with a wide substrate scope. magnified image