Key points are not available for this paper at this time.
An approach for direct trifluoromethylation of internal olefins of -oxoketene dithioacetals has been achieved by using Ru(bpy) 3 Cl 2 as photocatalyst and Togni's reagent as trifluoromethylating agent under irradiation with visible light. Under a nitrogen atmosphere, a mixture of -oxoketene dithioacetal (0.1 mmol), Togni's reagent (0.15 mmol), Ru(bpy) 3 Cl 2 (0.005 mmol), and Na 2 CO 3 (0.3 mmol) in DMSO (1 mL) was stirred at room temperature for 72 h under 5 W Blue LEDS, which led to the trifluoromethylated products in 40%90% yield. This protocol provides an efficient and easy access to prepare trifluoromethylated dithioalkyl -oxoketene acetals under mild conditions, and is highlighted by its operational simplicity and avoiding using toxic reagent. Furthermore, the gram-scale reaction of 1a suggested the potential application of this protocol in organic synthesis.
Gou et al. (Sun,) studied this question.