Key points are not available for this paper at this time.
activation, high yield, and highly enantioselective C-H oxidation rely on the synergistic cooperation of a sterically bulky manganese catalyst and an oxidatively robust alkanoic acid. This represents the first example of nonenzymatic highly enantioselective oxidation of nonactivated methylenic sites. Furthermore, the principles of catalyst design disclosed in this work constitute a unique platform for further development of stereoselective C-H oxidation reactions.
Milan et al. (Wed,) studied this question.