Is impaired Left Ventricular Global Longitudinal Strain (LV GLS) associated with biomarkers, diastolic dysfunction, quality of life, or exercise capacity in patients with HFpEF?
In HFpEF patients, impaired LV GLS indicates covert systolic dysfunction and correlates with biomarkers of wall stress and diastolic dysfunction, but does not correlate with quality of life or exercise capacity.
Impaired LV GLS is common among HFpEF patients, indicating the presence of covert systolic dysfunction despite normal LV ejection fraction. Impaired LV GLS was associated with biomarkers of wall stress and collagen synthesis and diastolic dysfunction but not with quality of life or exercise capacity, suggesting other processes may be more responsible for these aspects of the HFpEF syndrome.
DeVore et al. (Tue,) studied this question.