Characteristics and comparison of colorectal cancer incidence in Beijing with other regions in the world

// Zhongmin Li 1 , Lei Yang 2 , Changzheng Du 3 , Xuedong Fang 1 , Ning Wang 2 , Jin Gu 3, 4, 5 1 Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, China 2 Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing Office for Cancer Prevention and Control, Peking University Cancer Hospital and Institute, Beijing, China 3 Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Surgery Peking University Cancer Hospital and Institute, Beijing, China 4 Department of General Surgery, Peking University Shougang Hospital, Beijing, China 5 Tsinghua-Peking Joint Center for Life Sciences, Peking University, Beijing, China Correspondence to: Jin Gu, email: zlgujin@126.com Ning Wang, email: bjwangning@126.com Keywords: Beijing, population-based, colorectal cancer, incidence, trend Received: December 28, 2016      Accepted: February 13, 2017      Published: February 21, 2017 ABSTRACT Background: Population-based epidemiologic studies about colorectal cancer are lacking in China. This study aims to provide a basis for colorectal cancer screening and prevention, through analysis and comparisons the characteristics of the trends in colorectal cancer incidence in Beijing and selected representative regions. Results: The annual incidence rate in Beijing region increased significantly, from 9.40/100,000 in 1998 to 18.61/100,000 in 2012. The stratified rate showed that the incidence of distal colon adenocarcinoma increased substantially in men, especially in those aged > 75 years and residing in urban areas. Although the incidence rate in Beijing is still lower than in Shanghai, Jiashan, and Hong Kong in China, it is increasing rapidly. Further, the incidence rate in Beijing is lower than in New York, Oxford and Osaka, but higher than in Mumbai and Kyadondo. The incidence trend in Beijing is increasing especially in older groups, while in other regions such as New York, it is decreasing in these age groups. Materials and Methods: Colorectal cancer incidence data were obtained from Beijing Cancer Registry and Cancer Incidence in Five Continents Plus database. All incidence rates were age-standardized according to Segi’s world population. Incidence trends were characterized by calculating the annual percent changes using the Joinpoint Regression Program. Conclusions: Compared with other regions, Beijing has a medium level of colorectal cancer incidence, however, it is increasing significantly. There are obvious differences in the cancer subsite, sex and age distributions between Beijing and other regions. Prevention and screening of colorectal cancer in Beijing should be strengthened.