March 30, 2017Pharmaceuticals88 citationsOpen Access

Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine

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Abstract

A review. Development of pharmaceutical antagonists of transient receptor potential melastatin 8 (TRPM8) have been pursued for the treatment of chronic pain and migraine. This review focuses on the current state of this progress.

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Weyer et al. (Thu,) studied this question.

synapsesocial.com/papers/6a83428fdcf10720d731f7b5 https://doi.org/https://doi.org/10.3390/ph10020037

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Therapeutic Targeting of TRP Channels - The TR(i)P to Pain Relief2011 · 61 citations
2Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain2015 · 82 citations
3Optimization of Potency and Pharmacokinetic Properties of Tetrahydroisoquinoline Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists2014 · 42 citations
4Role of TRPM8 in dorsal root ganglion in nerve injury-induced chronic pain2011 · 118 citations
5Pharmacological Blockade of TRPM8 Ion Channels Alters Cold and Cold Pain Responses in Mice2011 · 206 citations

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