Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

BACKGROUND: F-THK5351 brain uptake using PET and autoradiography. METHODS: F-THK5351 competition autoradiography studies in postmortem tissue were conducted using 150 and 500 nM selegiline. RESULTS: F-THK5351 uptake. CONCLUSIONS: F-THK5351 scans using reference region methods.