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Resident memory T cells in the skin mediate durable immunity to melanoma | Synapse

April 15, 2017

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Resident memory T cells in the skin mediate durable immunity to melanoma

BMBrian T. MalikDartmouth College KBKatelyn T. ByrnePortland State University JVJennifer L. VellaDartmouth College

Key Points

Key points are not available for this paper at this time.

Abstract

Resident memory CD8 T cells maintained in vitiligo-affected skin mediate long-lived protection against melanoma.

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Cite This Study

Malik et al. (Sat,) studied this question.

synapsesocial.com/papers/6a11f0cb0514fa642cccc508 https://doi.org/https://doi.org/10.1126/sciimmunol.aam6346

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1Impaired selectin-dependent leukocyte recruitment induces T-cell exhaustion and prevents chronic allograft vasculopathy and rejection2014 · 43 citations
2Tumor Regression and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8+ T Cells2003 · 929 citations
3Vitiligo is an independent favourable prognostic factor in stage III and IV metastatic melanoma patients: results from a single-institution hospital-based observational cohort study2009 · 186 citations
4Selective Stimulation of T Cell Subsets with Antibody-Cytokine Immune Complexes2006 · 875 citations
5Spontaneous Development of Psoriasis in a New Animal Model Shows an Essential Role for Resident T Cells and Tumor Necrosis Factor-α2004 · 516 citations