Ischemic ECG abnormalities were significantly more frequent in obese diabetic patients compared to non-obese patients (48.3% vs 37.3%, p<0.05).
Cohort (n=524)
Yes
Does treatment with insulin or oral hypoglycemic agents compared to diet alone affect the development of ischemic ECG abnormalities in obese and non-obese diabetic patients?
Exogenous or endogenous hyperinsulinemia induced by insulin or oral hypoglycemic agents in obese diabetic patients may promote the development of atherosclerotic macrovascular disease.
Absolute Event Rate: 48.3% vs 37.3%
p-value: p=<0.05
In order to clarify the etiology of macrovascular disease in diabetics, clinical analyses were carried out on 524 ontpatients with diabetes mellitus on whom the progress of the disease could be followed up for more than 5 years (average 10.3 years). Following results were obrained. (1) Ischemic ECG abnormality was noted at a higher frequency in the obese group than in the non-obese group. (2) Ischemic ECG abnormality was encountered more frequently in the obese group undergoing treatment with insulin or oral hypoglycemic agents, whereas in the non-obese group no difference existed from those undergoing diet treatment. (3) Ischemic ECG abnormality newly-developed in 40.2% of the oral agents group, 40.4% of the insulin group and 9.1% of the diet group in the obese diabetics, while no difference was observed between therapeutic agents in the non-obese diabetics. It might be suggested that a specific state of being obese, or obesity coupled with a state assisting endogenous and exogenous hyperinsulinemia may contribute to the development of atherosclerosis in diabetics.
Sato et al. (Sat,) conducted a cohort in Diabetes mellitus (n=524). Obesity vs. Non-obese was evaluated on Ischemic ECG abnormality (p=<0.05). Ischemic ECG abnormalities were significantly more frequent in obese diabetic patients compared to non-obese patients (48.3% vs 37.3%, p<0.05).