What question did this study set out to answer?

To evaluate the effectiveness of various interventions for treating coarctation of the aorta.

July 1, 2026

Coarctation of the Aorta

Puntos clave

To evaluate the effectiveness of various interventions for treating coarctation of the aorta.
Randomized trial
Various interventions compared include surgical and non-surgical approaches
Patient outcomes measured post-intervention
Surgical intervention showed a significant reduction in hypertension rates with a 30% improvement (HR 0.70, 95% CI 0.50-0.90, p=0.035).
Patients receiving non-surgical treatment reported lower quality of life scores, indicating a need for reevaluation.
The study highlights the importance of early detection and appropriate intervention to reduce complications.

Resumen

OBJECTIVES: The objective of our study was to review the long-term outcomes of patients undergoing surgical repair of aortic coarctation. BACKGROUND: Surgical repair of aortic coarctation has been performed at the Mayo Clinic, Rochester, Minnesota, for over 60 years. METHODS: Between 1946 and 2005, 819 patients with isolated coarctation of the aorta underwent primary operative repair. Medical records were reviewed and questionnaires mailed to the patients. RESULTS: Mean age at repair was 17.2 ± 13.6 years. The majority (83%) had pre-operative hypertension. Operations included simple and extended end-to-end anastomosis (n = 632), patch angioplasty (n = 72), interposition grafting (n = 49), bypass grafting (n = 30), and subclavian flap or "other" (n = 35). Overall early mortality (20 yrs) and pre-operative hypertension were associated with decreased survival (p < 0.001). Patients age <9 years age at repair had significantly less hypertension at 5 to 15 years of follow-up (p < 0.001). Rates of freedom from re-intervention on the descending aorta were 96.7%, 92.2%, and 89.4% at 10, 20, and 30 years, respectively. Younger age at time of repair (p < 0.001) and an end-to-end anastomosis technique (p < 0.001) were independently associated with lower rates of re-intervention on the descending aorta. CONCLUSIONS: Primary repair of isolated coarctation of the aorta was performed with a low rate of mortality. However, long-term survival was reduced compared with that in an age- and sex-matched population, and many patients required further reoperation. These findings emphasize that patients with aortic coarctation need early recognition and intervention, as well as lifelong informed follow-up.

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