Intensive statin therapy with rosuvastatin improved regional longitudinal systolic strain in the infarct area more than standard therapy after 1 month (-4.22% vs -2.48%; p=0.047).
RCT (n=140)
randomized
Does intensive statin therapy improve regional longitudinal systolic strain in patients with acute myocardial infarction?
Early high-dose rosuvastatin therapy improves regional longitudinal systolic strain in the infarct area in patients with AMI, with a trend toward greater improvement in those with abnormal glucose tolerance.
Absolute Event Rate: -4.22% vs -2.48%
p-value: p=0.047
OBJECTIVES: Abnormal glucose tolerance in patients with acute myocardial infarction (AMI) is associated with greater mortality and adverse cardiovascular effects. As statins possess a range of beneficial pleiotropic effects on the cardiovascular system, we sought to assess the cardioprotective effects of statins on left ventricular function in patients with AMI in relation to glycometabolic state. METHODS: In a prospective, randomized trial, 140 patients with AMI were randomized to intensive statin therapy receiving statin loading with 80 mg of rosuvastatin followed by 40 mg daily or standard statin therapy. Patients were assessed with an oral glucose tolerance test and their left ventricular (LV) function was assessed with speckle-tracking echocardiography measuring regional longitudinal systolic strain (RLSS) in the infarct area. RESULTS: Overall RLSS in the infarct area improved by a mean (±SD) of -4.22% (±5.19) in the intensive-care group and -2.48% (±4.01) in the usual-care group after 1 month (p = 0.047). In patients with abnormal glucose tolerance, RLSS improved by -5.01% (±5.28) in the intensive-care group and -2.15% (±4.22) in the usual-care group (p = 0.01). CONCLUSIONS: Early high-dose statin treatment improved RLSS in the infarct area in patients with AMI, and a trend of greater improvement was seen in patients with abnormal glucose tolerance.
Auscher et al. (Sun,) conducted a rct in acute myocardial infarction (n=140). Intensive statin therapy (rosuvastatin) vs. standard statin therapy was evaluated on regional longitudinal systolic strain (RLSS) in the infarct area (p=0.047). Intensive statin therapy with rosuvastatin improved regional longitudinal systolic strain in the infarct area more than standard therapy after 1 month (-4.22% vs -2.48%; p=0.047).