Neuronal AT1 receptors drive ADAM17-mediated ACE2 shedding in the brains of hypertensive patients, contributing to the pathophysiology of neurogenic hypertension.
Our data demonstrate that angiotensin II type 1 receptors promote ADAM17-mediated ACE2 shedding in the brain of hypertensive patients, leading to a loss in compensatory activity during neurogenic hypertension.
Xu et al. (Wed,) studied this question.
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