Age was significantly associated with normalized aortic diameter (R = 0.73), skewness (R = 0.76), and kurtosis (R = 0.74) of aortic velocity magnitude (all P < 0.001).
Cross-Sectional (n=98)
How do age and gender affect the distribution of blood flow velocity in the normal aorta as measured by 4D flow MRI?
Aortic hemodynamics measured by 4D flow MRI change significantly with age and gender, highlighting the need for age- and gender-matched controls in cardiovascular disease studies.
Effect estimate: R 0.76
p-value: p=<0.001
PURPOSE: To apply flow distribution analysis in the entire aorta across a wide age range from pediatric to adult subjects. MATERIAL AND METHODS: In all, 98 healthy subjects (age 9-78 years, 41 women) underwent 4D flow MRI at 1.5T and 3T for the assessment of 3D blood flow in the thoracic aorta. Subjects were categorized into age groups: group 1 (n = 9, 5 women): 9-15 years; group 2 (n = 13, 8 women): 16-20 years; group 3 (n = 27, 14 women): 21-39 years; group 4 (n = 40, 11 women): 40-59 years; group 5 (n = 9, 3 women): >60 years. Data analysis included the 3D segmentation of the aorta, aortic valve peak velocity, mid-ascending aortic diameter, and calculation of flow velocity distribution descriptors (mean, median, standard deviation, incidence of velocities >1 m/s, skewness, and kurtosis of aortic velocity magnitude). Ascending aortic diameter was normalized by body surface area. RESULTS: Age was significantly associated with normalized aortic diameter (R = 0.73, P 40 years) as compared with childhood (<21 years). Men and women revealed significant differences (P ≤ 0.05) for peak velocity, incidence, mean, median, standard deviation, and skewness, all adjusted by heart rate. CONCLUSION: Aortic hemodynamics significantly change with age and gender, indicating the importance of age- and gender-matched control cohorts for the assessment of the impact of cardiovascular disease on aortic blood flow. LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 5 J. Magn. Reson. Imaging 2018;47:487-498.
García et al. (Fri,) conducted a cross-sectional in Healthy subjects (n=98). 4D flow MRI vs. Age and gender groups was evaluated on Normalized aortic diameter, skewness, and kurtosis of aortic velocity magnitude (R 0.76, p=<0.001). Age was significantly associated with normalized aortic diameter (R = 0.73), skewness (R = 0.76), and kurtosis (R = 0.74) of aortic velocity magnitude (all P < 0.001).
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