AF patients had significantly elevated FVIII and VWF levels in both the femoral vein and left atrium compared to controls, but no significant intracardiac-specific hemostasis alterations.
Case-Control
AIMS: To identify intracardiac hemostasis or fibrinolysis abnormalities, which are associated with atrial fibrillation (AF) and increase the risk of thromboembolism. PATIENTS AND METHODS: -antiplasmin (PAP) complex, PAI-1 activity, and D-dimer were measured from all samples. RESULTS: Levels of FVIII and VWF were significantly elevated in the FV and LA of AF patients as compared to controls. TAT complex, FM, PAP complex, and D-dimer levels were significantly elevated in the LA as compared to FV samples in case of both groups, indicating a temporary thrombotic risk associated with the catheterization procedure. CONCLUSIONS: None of the investigated hemostasis or fibrinolysis parameters showed significant intracardiac alterations in AF patients as compared to non-AF controls. AF patients have elevated FVIII and VWF levels, most likely due to endothelial damage, presenting at both intracardiac and systemic level.
Tóth et al. (Sun,) conducted a case-control in Atrial Fibrillation. Measurement of hemostasis and fibrinolysis parameters vs. Non-AF controls was evaluated on Intracardiac hemostasis or fibrinolysis abnormalities. AF patients had significantly elevated FVIII and VWF levels in both the femoral vein and left atrium compared to controls, but no significant intracardiac-specific hemostasis alterations.