In patients with suspected deep vein thrombosis, the sensitivity of D-dimer testing was 16.8% lower in patients under 60 years compared to those 60 years and older.
Observational (n=500)
Single-blind
No
Does an age-adapted D-dimer threshold improve diagnostic accuracy in younger patients (<60 years) with suspected deep vein thrombosis?
Standard D-dimer testing has significantly lower sensitivity in younger patients (<60 years) with suspected DVT, suggesting that a lower age-adapted threshold (0.25 mg/L FEU) may be necessary to safely rule out thrombosis.
Effect estimate: ∆-16.8%
Absolute Event Rate: 76.1% vs 92.9%
Previous reports have investigated the impact of age on D-Dimer testing in elderly individuals with suspected deep vein thrombosis (DVT), but data on the age-related diagnostic value of D-dimer in a sample covering a broad age range are limited. The present study determined age-specifically the diagnostic accuracy of D-dimer and compared it to C-reactive protein (CRP), a marker of inflammation, in 500 patients with suspected DVT from the VTEval project (NCT02156401). Sensitivity of D-dimer was lower in patients 0.05). In conclusion, these data outline a clinically-relevant limitation of D-dimer testing among younger patients with suspected DVT indicating a necessity for age-adapted cut-off values. Further research is required to decrypt the role of inflammation in the pathophysiology and diagnosis of venous thrombosis.
Prochaska et al. (Wed,) conducted a observational in Suspected deep vein thrombosis (n=500). D-dimer testing vs. Patients ≥ 60 years was evaluated on Sensitivity of D-dimer testing for DVT (∆-16.8%). In patients with suspected deep vein thrombosis, the sensitivity of D-dimer testing was 16.8% lower in patients under 60 years compared to those 60 years and older.
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