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Cucurbit7uril (CB7), belonging to the cucurbitnuril family (CBn, n = 5-8, 10, or 13-15), may form host-guest complexes with a variety of small molecules of biomedical interest. The physical and chemical properties of the complexed drugs are often improved as a result of this complexation, suggesting the potential application of CB7 as a pharmaceutical excipient. This review has summarized the most recent research progress reported between 2011 and early 2017 regarding the biocompatibility of CB7 and the influence of CB7 on the stability, solubility, biouptake, and biological activities (including therapeutic efficacies and toxicities) of guest drug molecules. Through this systemic summary and analysis, we intend to stimulate further research efforts in this area and promote the use of CB7 as an emerging pharmaceutical excipient to improve various properties of drug molecules (or active pharmaceutical ingredients).
Kuok et al. (Thu,) studied this question.