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Disruption of NAD synthesis caused a deficiency of NAD and congenital malformations in humans and mice. Niacin supplementation during gestation prevented the malformations in mice. (Funded by the National Health and Medical Research Council of Australia and others.).
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Hongjun Shi
Westlake University
Annabelle Enriquez
Victor Chang Cardiac Research Institute
Melissa Rapadas
Garvan Institute of Medical Research
New England Journal of Medicine
The University of Queensland
The University of Sydney
UNSW Sydney
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Shi et al. (Wed,) studied this question.
synapsesocial.com/papers/69df12e73b0ba53fb37a1203 — DOI: https://doi.org/10.1056/nejmoa1616361
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