miR-21 promotes cardiac fibrosis after myocardial infarction by targeting Smad7, highlighting it as a potential therapeutic target.
These findings suggested that miR-21 has a critical role in CF activation and cardiac fibrosis after MI through via TGF-β/Smad7 signaling pathway. Thus, miR-21 promises to be a potential therapy in treatment of cardiac fibrosis after MI.
Yuan et al. (Sun,) studied this question.