Echocardiographic hemodynamic classification revealed differing subgroup distributions between HFrEF and HFpEF (P<.0001), with higher readmission rates in HFpEF at 30 days and 18 months.
Observational (n=176)
Does a novel echocardiographic hemodynamic classification based on stroke volume index and E/E' reveal differences in profiles and outcomes between HFrEF and HFpEF patients?
A novel echocardiographic classification based on stroke volume index and E/E' demonstrates distinct hemodynamic profiles between HFrEF and HFpEF, with HFpEF patients experiencing higher readmission rates.
BACKGROUND AND AIM: Dividing patients with heart failure (HF) based solely on ejection fraction (EF) may over simplify the hemodynamic states of these patients. We describe a novel echo-derived hemodynamic HF model based on flow (stroke volume index SVI) and left atrial pressure (E:E') correlates. METHODS: ) and E/E' (≥ or <15). Group A: normal flow and normal filling pressure, Group B: normal flow but high filling pressure, Group C: low flow and low filling pressure, and Group D: low flow and high filling pressure. RESULTS: A total of 176 patients were enrolled, 123 patients had HFrEF and 53 patients had HFpEF. Baseline characteristics were not statistically significant in both groups. In HFrEF, most patients were in group D compared to a heterogeneous distribution in HFpEF (P<.0001). In HFrEF, there was a trend toward an increase in B-type natriuretic peptide levels with a decrease in SVI and increase in E/E' (P=.05) but not in HFpEF. There was no difference in death, major adverse cardiac events, but a higher readmissions rate in the HFpEF group at 30 days and 18 months. CONCLUSIONS: Hemodynamic subgroups differ between HFrEF and HFpEF. There is no difference in major adverse cardiovascular events between both groups with increased readmissions in HPpEF patients. Larger studies may help assess the impact of echo-derived hemodynamic state on clinical outcome.
Abbas et al. (Sat,) conducted a observational in Heart failure (n=176). Echocardiographic hemodynamic classification (SVI and E/E') vs. HFrEF vs HFpEF was evaluated on Death, major adverse cardiac events, and readmissions. Echocardiographic hemodynamic classification revealed differing subgroup distributions between HFrEF and HFpEF (P<.0001), with higher readmission rates in HFpEF at 30 days and 18 months.