Feature tracking CMR reveals abnormal strain in preclinical arrhythmogenic right ventricular dysplasia/ cardiomyopathy: a multisoftware feasibility and clinical implementation study

Structured PICO

Does feature tracking CMR strain analysis distinguish preclinical and overt ARVD/C from control subjects?

Population

Patients with overt arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C), preclinical ARVD/C subjects, and control subjects

Intervention

Feature tracking cardiovascular magnetic resonance (FT-CMR) strain analysis using four different software methods

Comparator

Control subjects

Outcome

Ability to distinguish overt and preclinical ARVD/C from control subjects using global and subtricuspid strain valuessurrogate

FT-CMR subtricuspid strain analysis shows potential for identifying early, preclinical ARVD/C prior to overt disease expression, despite significant intersoftware variability.

Abstract

Despite large intersoftware variability of FT-CMR derived strain values, all four software methods distinguished overt ARVD/C patients from control subjects by both global and subtricuspid strain values. In the subtricuspid region, one software package distinguished preclinical from control subjects, suggesting the potential to identify early ARVD/C prior to overt disease expression.

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