Heart rate dynamics during exercise and recovery showed high intra-individual reproducibility over a 3-year period, with intra-individual correlation significantly exceeding inter-individual correlation (0.92 vs 0.87, p<0.01).
Observational (n=821)
Heart rate dynamics during exercise and recovery show moderate to strong intra-individual reproducibility over a 3-year period, supporting their potential reliability as clinical biomarkers.
Absolute Event Rate: 0.92% vs 0.87%
p-value: p=<0.01
BACKGROUND: The heart rate (HR) response to exercise provides useful information about the autonomic function and has prognostic value, but its reproducibility over a long period of time, a critical requirement for using it as a clinical biomarker, is undetermined. AIM: To determine the intra-individual reproducibility of HR dynamics during sub-maximum exercise and one minute recovery. METHODS: 1187 individuals from the Cardio physical fitness assessment test of the UK Biobank repeated a standard exercise stress test twice (recall time 34.2 ± 2.8 months) and were prospectively studied. RESULTS: 821 individuals complied with inclusion criteria for reproducibility analysis, including peak workload differences between assessments ≤10 W. Intra-individual correlation between HR profile during the first and the second assessment was very high and higher than inter-individual correlation (0.92±0.08 vs 0.87±0.11, p<0.01). Intra-individual correlation of indices describing HR dynamics was: ρ = 0.81 for maximum HR during exercise; ρ = 0.71 for minimum HR during recovery; ρ = 0.70 for HR changes during both exercise and recovery; Intra-individual correlation was higher for these indices of HR dynamics than for resting HR (ρ = 0.64). Bland-Altman plots demonstrated good agreement between HR indices estimated during the first and second assessment. A small but consistent bias was registered for all repeated measurements. The intra-individual consistency of abnormal values was about 60-70%. CONCLUSIONS: The HR dynamics during exercise and recovery are reproducible over a period of 3 years, with moderate to strong intra-individual reproducibility of abnormal values.
Orini et al. (Tue,) conducted a observational in General population (n=821). Repeated exercise stress test vs. Inter-individual correlation was evaluated on Intra-individual correlation of HR profile (p=<0.01). Heart rate dynamics during exercise and recovery showed high intra-individual reproducibility over a 3-year period, with intra-individual correlation significantly exceeding inter-individual correlation (0.92 vs 0.87, p<0.01).