September 13, 2017Open Access
Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke
Structured PICO
Does PFO closure combined with antiplatelet therapy reduce stroke recurrence compared to antiplatelet therapy alone in patients with recent cryptogenic stroke attributed to PFO with an associated atrial septal aneurysm or large interatrial shunt?
P
Population
Patients with a recent cryptogenic stroke attributed to patent foramen ovale (PFO) with an associated atrial septal aneurysm or large interatrial shunt
I
Intervention
Patent foramen ovale (PFO) closure combined with antiplatelet therapy
C
Comparator
Antiplatelet therapy alone
O
Outcome
Stroke recurrencehard clinical
In patients with recent cryptogenic stroke and high-risk PFO features, PFO closure combined with antiplatelet therapy reduces the risk of stroke recurrence compared to antiplatelet therapy alone, albeit with an increased risk of atrial fibrillation.
Abstract
Among patients who had had a recent cryptogenic stroke attributed to PFO with an associated atrial septal aneurysm or large interatrial shunt, the rate of stroke recurrence was lower among those assigned to PFO closure combined with antiplatelet therapy than among those assigned to antiplatelet therapy alone. PFO closure was associated with an increased risk of atrial fibrillation. (Funded by the French Ministry of Health; CLOSE ClinicalTrials.gov number, NCT00562289 .).
Connected Papers
Building similarity graph...
Analyzing shared references across papers
Discussion
Loading...
Authors
Jean‐Louis Mas
Vascular Medicine
G
Geneviève Dérumeaux
Cardiac Imaging
B
B. Guillon
Thales (Portugal)
Journals
New England Journal of Medicine
Actions
Institutions
Inserm
Université Paris Cité
Sorbonne Université
References and Citations
Connected Papers
Building similarity graph...
Analyzing shared references across papers
Discussion
Loading...